PI3K-IN-16

Names

[ Name ]:
PI3K-IN-16

Biological Activity

[Description]:

PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft.

[References]

References 1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. View Related Products by Target PI3K

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₆FN₃O₅

[ Molecular Weight ]:
467.497

Related Compounds

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