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Rocaglamide C

Names

[ CAS No. ]:
189322-67-6

[ Name ]:
Rocaglamide C

[Synonym ]:
(1R,2R,3S,3aR,8bS)-1,8b-Dihydroxy-3a-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-2-carboxamide
1H-Benzo[b]cyclopenta[d]furan-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-3a-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-

Biological Activity

[Description]:

Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC50s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. eng L, et al. Two new lignans from twigs of Aglaia odorata. J Asian Nat Prod Res. 2016;18(2):147-52.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
704.8±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H31NO8

[ Molecular Weight ]:
521.56

[ Flash Point ]:
380.0±32.9 °C

[ Exact Mass ]:
521.204956

[ PSA ]:
117.92000

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.648

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds