Danshenol B

Names

[ Name ]:
Danshenol B

[Synonym ]:
Phenanthro(1,2-b)furan-11(2H)-one,1,6,7,8,9,10-hexahydro-10-hydroxy-1,6,6-trimethyl-10-(2-oxopropyl)-,(1R-trans)
Phenanthro(1,2-b)furan-11(2H)-one,1,6,7,8,9,10-hexahydro-10-hydroxy-1,6,6-trimethyl-10-(2-oxopropyl)-,(1R,10S)
Danshenol B

Biological Activity

[Description]:

Danshenol B is a diterpenoid. Danshenol B has strong aldose reductase (AR) inhibitory activity with IC50 value of 0.042μM. Danshenol B can be used for the research of diabetic related complication resulted by metabolic abnormality, such as cataracts, retinopathy, neuropathy, and nephropathy[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. Tezuka Y, et al. Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge. Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11.

Chemical & Physical Properties

[ Density]:
1.24±0.1 g/cm3

[ Boiling Point ]:
501.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₆O₄

[ Molecular Weight ]:
354.43900

[ Exact Mass ]:
354.18300

[ PSA ]:
63.60000

[ LogP ]:
3.42730

[ Vapour Pressure ]:
7.19E-11mmHg at 25°C

Related Compounds

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