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Desmethylselegiline

Names

[ CAS No. ]:
18913-84-3

[ Name ]:
Desmethylselegiline

[Synonym ]:
EINECS 200-659-6

Biological Activity

[Description]:

Nordeprenyl is the metabolite of Deprenyl. Deprenyl is a potent, selective and irreversible inhibitor of MAO-B[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Yoshida T, et, al. Metabolism of deprenyl, a selective monoamine oxidase (MAO) B inhibitor in rat: relationship of metabolism to MAO-B inhibitory potency. Xenobiotica. 1986 Feb;16(2):129-36.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H15N

[ Molecular Weight ]:
173.25

[ Flash Point ]:
9℃

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
7-16-36/37-45

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

Articles

Simultaneous determination of selegiline and desmethylselegiline in human body fluids by headspace solid-phase microextraction and gas chromatography-mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 844(2) , 283-91, (2006)

A method for the simultaneous determination of selegiline and its metabolite, desmethylselegiline, in human whole blood and urine is presented. The method, which combines a fiber-based headspace solid...

Modulation of neuroendocrine--immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer.

Mech. Ageing Dev. 123(8) , 1065-79, (2002)

The aging process is characterized by a decline in cellular functions of diverse systems of the body, including the neuroendocrine-immune network. One neuroendocrinological theory of aging is based on...

Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse.

J. Neural Transm. Suppl. (72) , 165-73, (2007)

(-)-Deprenyl is a selective irreversible inhibitor of MAO-B. The parent compound is responsible for the enzyme inhibitory effect, but its metabolites are also playing a role in the complex pharmacolog...


More Articles


Related Compounds

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