(±)-Propionylcarnitine chloride

Propionyl-DL-carnitine chloride is a carnitine derivative. Propionyl-DL-carnitine chloride can be used for the research of inflammation[1][2][3][4].

Research Areas >> Inflammation/Immunology

Propionyl-DL-carnitine chloride shows protection to beta-thalassaemic erythrocytes from oxidative stress[1]. Propionyl-DL-carnitine chloride increases production of 14CO2 from [1-14C]pyruvate and increases the rate of formation of acetyl camitine from pyruvate[2]. Propionyl-DL-carnitine chloride allows the endothelial cells to maintain their functionality and regulatory role on vessel activity for a longer time and decreases the formation of oxygen reactive species due to xanthine oxidase activity on hypoxanthine formed by adenine nucleotide catabolism[4].

Propionyl-DL-carnitine chloride (2 mM/kg; p.o. once daily for 4 weeks) affects plasma and urine total carnitine concentrations of mice[3]. Animal Model: Adult age-matched male C57BL/6 mice[3] Dosage: 2 mM/kg Administration: Oral gavage; 2 mM/kg/day for 4 weeks Result: Increased plasma and urine total carnitine concentrations, but showed no effect on the skeletal muscle carnitine content of mice.