2,3-Dibromopropionyl chloride
Names
[ CAS No. ]:
18791-02-1
[ Name ]:
2,3-Dibromopropionyl chloride
[Synonym ]:
Propionyl chloride,2,3-dibromo
MFCD00000712
2,3-dibromo propanoyl chloride
1,2-dibromopropionyl chloride
chloroanhydride of 1,2-dibromopropionic acid
2,3-Dibromopropionyl chloride
EINECS 242-575-2
Chemical & Physical Properties
[ Density]:
2.181 g/mL at 25 °C(lit.)
[ Boiling Point ]:
191-193 °C(lit.)
[ Molecular Formula ]:
C3H3Br2ClO
[ Molecular Weight ]:
250.31600
[ Flash Point ]:
152 °F
[ Exact Mass ]:
247.82400
[ PSA ]:
17.07000
[ LogP ]:
1.91020
[ Vapour Pressure ]:
0.5mmHg at 25°C
[ Index of Refraction ]:
n20/D 1.542(lit.)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UG6657500
- CHEMICAL NAME :
- Propionyl chloride, 2,3-dibromo-
- CAS REGISTRY NUMBER :
- 18791-02-1
- BEILSTEIN REFERENCE NO. :
- 1749801
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C3-H3-Br2-Cl-O
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(4),90,1984
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1360 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(4),90,1984
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 19200 mg/m3
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 49(4),90,1984
Safety Information
[ Symbol ]:
GHS05, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H302-H314-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
C:Corrosive;
[ Risk Phrases ]:
R34;R36/37
[ Safety Phrases ]:
S23-S26-S27-S28-S36/37/39-S45
[ RIDADR ]:
UN 3265 8/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
UG6657500
[ Packaging Group ]:
II
[ Hazard Class ]:
8
[ HS Code ]:
2915900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2915900090
[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%
Articles
J. Med. Chem. 24(9) , 1059-63, (1981)
A series of 2,3-diaminopropionanilides was synthesized by acylation of mono- and disubstituted aniline derivatives with 2,3-dibromopropionyl chloride and subsequent amination with the appropriate seco...
Chiral synthesis of both enantiomers of 1, 4-dideoxy-1, 4-immolyxitol and 1, 4-dideoxy-1, 4-iminoribitol. Takano S, et al.Tetrahedron Asymmetry 3(6) , 681-84, (1992)
Concise enantioselective synthesis of acromelic acid A. Takano S, et al.
J. Am. Chem. Soc. 109(18) , 5523-24, (1987)