BMS-770767

Names

[ Name ]:
BMS-770767

[Synonym ]:
(1s,4s)-4-[8-(2-Chlorophenoxy)[1,2,4]triazolo[4,3-a]pyridin-3-yl]bicyclo[2.2.1]heptan-1-ol
Bicyclo[2.2.1]heptan-1-ol, 4-[8-(2-chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-
4-[8-(2-Chlorophenoxy)-1,2,4-triazolo[4,3-a]pyridin-3-yl]-bicyclo[2.2.1]heptan-1-ol
BMS-770767

Biological Activity

[Description]:

BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Brad D Maxwell, et al. The synthesis and analysis of [phenyl-14 C(U)]BMS-770767 and [13 C6 ]BMS-770767 for use in discovery biotransformation, human ADME and bioanalytical studies. J Labelled Comp Radiopharm. 2016 Dec;59(14):657-664.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₁₈ClN₃O₂

[ Molecular Weight ]:
355.82

[ Exact Mass ]:
355.108765

[ LogP ]:
3.45

[ Index of Refraction ]:
1.726

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.