(S,E)-Ethyl 4-((S)-2-((Tert-Butoxycarbonyl)Amino)-N,3,3-Trimethylbutanamido)-2,5-Dimethylhex-2-Enoate

Names

[ Name ]:
(S,E)-Ethyl 4-((S)-2-((Tert-Butoxycarbonyl)Amino)-N,3,3-Trimethylbutanamido)-2,5-Dimethylhex-2-Enoate

[Synonym ]:
MFCD29472352
2-Hexenoic acid, 4-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3,3-dimethyl-1-oxobutyl]methylamino]-2,5-dimethyl-, ethyl ester, (2E,4S)-
Ethyl (2E,4S)-2,5-dimethyl-4-[methyl(3-methyl-N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-valyl)amino]-2-hexenoate

Biological Activity

[Description]:

Taltobulin intermediate-4 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
511.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₄₀N₂O₅

[ Molecular Weight ]:
412.56

[ Flash Point ]:
263.0±28.7 °C

[ Exact Mass ]:
412.293732

[ LogP ]:
5.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.476

Related Compounds

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