Bimosiamose

Names

[ Name ]:
Bimosiamose

[Synonym ]:
bimosiamose
[1,1'-Biphenyl]-3-acetic acid, 3',3''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
97B5KCW80W
2,2'-{1,6-Hexanediylbis[6'-(α-D-mannopyranosyloxy)-3',3-biphenyldiyl]}diacetic acid
8074

Biological Activity

[Description]:

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 88 μM (E-selectin), 20 μM (P-selectin), 86 μM (L-selectin)[1]

[In Vitro]

Bimosiamose is a pan-selectin antagonist, inhibits E-, P-, and L-selectin with IC50s of 88 μM, 20 μM, and 86 μM, respectively, and can be used in the research of inflammatory disease[1].

[In Vivo]

Bimosiamose (25 mg/kg, i.v.) significantly improves the survival in rats subjected to severe hepatic ischemia and reperfusion. Bimosiamose also causes lower ALT enzyme levels and decreases neutrophil infiltration[1].

[References]

[1]. Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1051.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₆H₅₄O₁₆

[ Molecular Weight ]:
862.911

[ Flash Point ]:
309.7±27.8 °C

[ Exact Mass ]:
862.341187

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.649

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds

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