5-Aminolevulinic acid-d2 hydrochloride

Names

[ CAS No. ]:
187237-35-0

[ Name ]:
5-Aminolevulinic acid-d2 hydrochloride

[Synonym ]:
5-Aminolevulinic-2,2-D2 AcidHCI
5-Aminolevulinic-2,2-D2 AcidCI
2,2-dideutero-5-aminolevulinic acid hydrochloride
5-AMinolevulinic-d2 Acid HCl

Biological Activity

[Description]:

5-Aminolevulinic acid-d2 (hydrochloride) is deuterium labeled 5-Aminolevulinic acid (hydrochloride).

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Autophagy >> Mitophagy
Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Stummer, W., et al., Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial. Lancet Oncol, 2006. 7(5): p. 392-401.

[3]. Eyupoglu, I.Y., et al., Improving the extent of malignant glioma resection by dual intraoperative visualization approach. PLoS One, 2012. 7(9): p. e44885.

Chemical & Physical Properties

[ Molecular Formula ]:
C5H8D2ClNO3

[ Molecular Weight ]:
169.60

[ Exact Mass ]:
169.04700

[ PSA ]:
80.39000

[ LogP ]:
0.88130

Related Compounds