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AA-CW236

Names

[ CAS No. ]:
1869921-96-9

[ Name ]:
AA-CW236

[Synonym ]:
4-(2-(5-(Chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole
AA-CW236
5-(Chloromethyl)-1-[2-(3,5-dimethyl-1,2-oxazol-4-yl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole
Isoxazole, 4-[2-[5-(chloromethyl)-4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]ethyl]-3,5-dimethyl-

Biological Activity

[Description]:

A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency; exhibits a high degree of selectivity towards MGMT, strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay.

[References]

References 1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5. View Related Products by Target DNA Methyltransferase (DNMT)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
535.0±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H16ClF3N4O2

[ Molecular Weight ]:
400.783

[ Flash Point ]:
277.4±32.9 °C

[ Exact Mass ]:
400.091400

[ LogP ]:
3.46

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
2-8°C

Related Compounds