SU5204

Names

[ Name ]:
SU5204

[Synonym ]:
MFCD04651331

Biological Activity

[Description]:

SU5204, a tyrosine kinase inhibitor extracted from patent US5792783A, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR2:4 μM (IC50)

HER2:51.5 μM (IC50)

[References]

[1]. Peng Cho Tang, et al. 3-heteroaryl-2-indolinone compounds for the treatment of disease. US5792783A.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₅NO₂

[ Molecular Weight ]:
265.30700

[ Exact Mass ]:
265.11000

[ PSA ]:
41.82000

[ LogP ]:
3.66310

Related Compounds

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