hVEGF-IN-2

Names

[ CAS No. ]:
186610-88-8

[ Name ]:
hVEGF-IN-2

Biological Activity

[Description]:

hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific drugs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR1:2.5 μM (IC50)

PDGF:33.1 μM (IC50)


[In Vitro]

hVEGF-IN-2 (0-100 μM) shows the inhibitory activities to particular RTKs at the cellular level with IC50 values of 2.5, 33.1, >100, >100 and >100 nM for VEGF, PDGF, EGF, HER-2 and IGF-1, respectively[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C19H18N2O2

[ Molecular Weight ]:
306.37


Related Compounds