5-phenylpyrimidine-2,4-diamine

Names

[ CAS No. ]:
18588-49-3

[ Name ]:
5-phenylpyrimidine-2,4-diamine

[Synonym ]:
5-Phenyl-pyrimidin-2,4-diyldiamin
5-phenyl-pyrimidine-2,4-diamine
Pyrimidine,2,4-diamino-5-phenyl
2,4-Diamino-5-phenylpyrimidine
5-phenyl-pyrimidine-2,4-diyldiamine
2,4-Diamino-5-phenyl-pyrimidin

Chemical & Physical Properties

[ Density]:
1.277 g/cm3

[ Boiling Point ]:
455.4ºC at 760 mmHg

[ Molecular Formula ]:
C10H10N4

[ Molecular Weight ]:
186.21300

[ Exact Mass ]:
186.09100

[ PSA ]:
79.28000

[ LogP ]:
1.16820

[ Vapour Pressure ]:
1.76E-08mmHg at 25°C

[ Index of Refraction ]:
1.686

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8199000
CHEMICAL NAME :
Pyrimidine, 2,4-diamino-5-phenyl-
CAS REGISTRY NUMBER :
18588-49-3
BEILSTEIN REFERENCE NO. :
0146163
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H10-N4
MOLECULAR WEIGHT :
186.24
WISWESSER LINE NOTATION :
T6N CNJ BZ DZ ER

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
REFERENCE :
SJDBA9 Soviet Journal Developmental Biology (English Translation). Translation of Ontogenez. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1970- Volume(issue)/page/year: 7,45,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
25 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy, Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 71(7),29,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy, Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 71(7),29,1976
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
100 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
AAGEAA Arkhiv Anatomii, Gistologii i Embriologii. Archives of Anatomy, Histology and Embryology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-101, 1916-91. Discontinued Volume(issue)/page/year: 71(7),29,1976

Related Compounds