TAK-981

Names

[ Name ]:
TAK-981

[Synonym ]:
MFCD32062692

Biological Activity

[Description]:

TAK-981 is a first in class and selective inhibitor of the SUMOylation enzymatic cascade, with potential immune-activating and antineoplastic activities[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

Research Areas >> Inflammation/Immunology

[Target]

SUMOylation[1].

[In Vitro]

TAK-981 is able to increase the production of type 1 interferon (IFN), thereby increasing type 1 IFN-mediated signaling, activating innate effector cells and enhancing the antitumor innate immune responses[1].

[In Vivo]

A single sub-cutaneous injection of TAK-981 in naive Balb/c mice at the brachial lymph nodes induces activation of DCs[2].

[References]

[1]. Sumoylation inhibitor TAK-981.

[2]. TAK-981.

Chemical & Physical Properties

[ Density]:
1.474±0.06 g/cm3(Predicted)

[ Boiling Point ]:
836.1±75.0 °C(Predicted)

[ Molecular Formula ]:
C₂₅H₂₈ClN₅O₅S₂

[ Molecular Weight ]:
578.10

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

TAK-981

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds