LSD1 inhibitor 24

Names

[ Name ]:
LSD1 inhibitor 24

Biological Activity

[Description]:

LSD1 inhibitor 24 is a novel potent, selective lysine-specific demethylase 1 (LSD1) inhibitor with IC50 of 1 nM, induces CD11b expression in THP-1 cells with EC50 of 8 nM; demonstrates attenuating the hERG inhibition and improving oral bioavailability.

[References]

References 1. Nie Z, et al. Bioorg Med Chem Lett. 2018 Nov 3. pii: S0960-894X(18)30855-2. View Related Products by Target Histone Demethylase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅ClFN₇O

[ Molecular Weight ]:
505.982

Related Compounds

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