2-(4-(2-Amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

Names

[ Name ]:
2-(4-(2-Amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

[Synonym ]:
MFCD29035152
1H-Indole-3-acetamide, 4-(2-amino-2-oxoethoxy)-2-ethyl-α-oxo-1-(phenylmethyl)-
2-[4-(2-Amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl]-2-oxoacetamide
2-(4-(2-Amino-2-oxoethoxy)-1-benzyl-2-ethyl-1H-indol-3-yl)-2-oxoacetamide

Biological Activity

[Description]:

hnps-PLA-IN-1 (compound 5aa), a indole-3-acetamide, is a hnps-PLA2 inhibitor (IC50=0.124 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

[Target]

IC50: 0.124 μM (hnps-PLA2)[1]

[References]

[1]. Draheim SE, et al. Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides. J Med Chem. 1996 Dec 20;39(26):5159-75.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
709.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₁N₃O₄

[ Molecular Weight ]:
379.41

[ Flash Point ]:
382.6±35.7 °C

[ Exact Mass ]:
379.153198

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.639

[ Storage condition ]:
-20℃