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Brevifolincarboxylic acid

Names

[ CAS No. ]:
18490-95-4

[ Name ]:
Brevifolincarboxylic acid

[Synonym ]:
Benzo[d]cyclopenta[b]pyran-1-carboxylic acid, 1,2,3,5-tetrahydro-7,8,9-trihydroxy-3,5-dioxo-
brevifolincarboxylic acid
7,8,9-Trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrocyclopenta[c]isochromene-1-carboxylic acid

Biological Activity

[Description]:

Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Aryl Hydrocarbon Receptor
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

IC50: 323.46 μM (α-glucosidase) (Brevifolincarboxylic acid)[3]


[References]

[1]. Chen X, et al. Simultaneous isolation and purification of gallic acid and brevifolincarboxylic acid from Polygonum capitatum by high-speed counter-current chromatography. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(15):1957-60.

[2]. Amakura Y, et al. Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Pharm Bull. 2003 Dec; 26(12):1754-60.

[3]. Liu M, et al. Separation of α-glucosidase inhibitors from Potentilla kleiniana Wight et Arn using solvent and flow-rate gradient high-speed counter-current chromatography target-guided by ultrafiltration HPLC-MS screening. Phytochem Anal. 2019 May 6.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
758.5±60.0 °C at 760 mmHg

[ Melting Point ]:
250 °C

[ Molecular Formula ]:
C13H8O8

[ Molecular Weight ]:
292.198

[ Flash Point ]:
296.2±26.4 °C

[ Exact Mass ]:
292.021912

[ PSA ]:
145.27000

[ LogP ]:
0.99

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.802

Related Compounds