TAS4464

Names

[ CAS No. ]:
1848959-10-3

[ Name ]:
TAS4464

[Synonym ]:
MFCD32067967

Biological Activity

[Description]:

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> NEDD8-activating Enzyme

[Target]

IC50：0.955 nM (NAE)[1]

[In Vitro]

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.

[References]

[1]. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₃FN₆O₆S

[ Molecular Weight ]:
506.51

Related Compounds

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