FF-10502

Names

[ Name ]:
FF-10502

[Synonym ]:
2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)-
4-Amino-1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)-2(1H)-pyrimidinone

Biological Activity

[Description]:

[In Vitro]

FF-10502 (FF-10502-01) is a pyrimidine nucleoside antimetabolite that shows growth inhibition of pancreatic cancer cell lines with IC50 of 60-330 nM; FF-10502 is far more potent than gemcitabine in inhibiting DNA polymerase ��, significantly induces concentration-dependent cell death in accordance with enhanced DNA damage in combination with DNA damage inducers (H2O2, cisplatin, and temozolomide); also demonstrates complete tumor growth suppression in in vivo patient-derived xenograft models with gemcitabine-resistant pancreatic cancer cells.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
516.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₂FN₃O₃S

[ Molecular Weight ]:
261.273

[ Flash Point ]:
266.2±32.9 °C

[ Exact Mass ]:
261.058350

[ LogP ]:
-1.73

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.754

Related Compounds

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