SH-BC-893

Names

[ Name ]:
SH-BC-893

Biological Activity

[Description]:

SH-BC-893 is a water-soluble, orally bioavailable synthetic sphingolipid that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways in cancer cells, activates protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve; selectively kills cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo.

[References]

References 1. Kim SM, et al. J Clin Invest. 2016 Nov 1;126(11):4088-4102. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₃₂ClNO

[ Molecular Weight ]:
325.921

Related Compounds

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