(+)-Dihydrocalanolide A

Names

[ Name ]:
(+)-Dihydrocalanolide A

[Synonym ]:
Dihydrocalanolide A

Biological Activity

[Description]:

(+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally active nonnucleoside inhibitor of Reverse Transcriptase. (+)-Dihydrocalanolide A can be used to HIV infection research[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Reverse Transcriptase

[In Vivo]

(+)-Dihydrocalanolide A (25 mg/kg; p.o.; single dose) 具有良好的药代动力学参数，在 CD2F1 小鼠中的口服生物利用度为 64%[1]。

[References]

[1]. Newman RA, et al. Pharmaceutical properties of related calanolide compounds with activity against human immunodeficiency virus. J Pharm Sci. 1998 Sep;87(9):1077-80.

Chemical & Physical Properties

[ Density]:
1.162g/cm3

[ Boiling Point ]:
509ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₈O₅

[ Molecular Weight ]:
372.45500

[ Flash Point ]:
173.8ºC

[ Exact Mass ]:
372.19400

[ PSA ]:
68.90000

[ LogP ]:
4.29950

[ Vapour Pressure ]:
3.5E-11mmHg at 25°C

[ Index of Refraction ]:
1.547

Related Compounds

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