Epoxyazadiradione

Names

[ Name ]:
Epoxyazadiradione

[Synonym ]:
ethyl 2,3-epoxybutyrate
ethyl 2,3-epoxybutanoate
Epoxyazadiradione
2,3-Epoxybutyric acid,ethyl ester
epoxy-2,3 butanoate d'ethyle
BUTYRIC ACID,2,3-EPOXY-,ETHYL ESTER
2,3-Epoxybuttersaeure-ethylester
3-methyl-oxiranecarboxylic acid ethyl ester

Biological Activity

[Description]:

Epoxyazadiradione is a limonoid purified from neem (Azadirachta indica) fruits. Epoxyazadiradione inhibits the tautomerase activity of MIF of both human (huMIF) and malaria parasites (Plasmodium falciparum (PfMIF) and Plasmodium yoelii (PyMIF)) non-competitively in a reversible fashion (Ki, 2.11-5.23 μM). Epoxyazadiradione has the potential against proinflammatory reactions induced by MIF of both malaria parasites and human[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Alam A, et al. Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor. J Biol Chem. 2012;287(29):24844-24861.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
569.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₃₄O₆

[ Molecular Weight ]:
466.56600

[ Flash Point ]:
298ºC

[ Exact Mass ]:
466.23600

[ PSA ]:
86.11000

[ LogP ]:
4.62910

[ Vapour Pressure ]:
5.76E-13mmHg at 25°C

[ Index of Refraction ]:
1.582

Related Compounds

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