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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Names

[ CAS No. ]:
1837-91-8

[ Name ]:
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

[Synonym ]:
Hexabromocyclohexane
JAK2 INHIBITOR II
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
MFCD00059127
1,2,3,4,5,6-Hexabromocyclohexane Benzene hexabromide
1,2,3,4,5,6-Hexabromcyclohexan
Cyclohexane, 1,2,3,4,5,6-hexabromo-
1,2,3,4,5,6-hexabromo-cyclohexan
Benzene Hexabromide

Biological Activity

[Description]:

Benzene hexabromide, a bromohydrocarbon, is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK

Chemical & Physical Properties

[ Density]:
2.9±0.1 g/cm3

[ Boiling Point ]:
388.9±42.0 °C at 760 mmHg

[ Melting Point ]:
82-85°C

[ Molecular Formula ]:
C6H6Br6

[ Molecular Weight ]:
557.536

[ Flash Point ]:
183.4±22.6 °C

[ Exact Mass ]:
551.556946

[ LogP ]:
5.01

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
Store at RT

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2903890090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2903890090

[ Summary ]:
2903890090. halogenated derivatives of cyclanic, cyclenic or cyclotherpenic hydrocarbons. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Nutritional state modulates growth hormone-stimulated lipolysis.

Gen. Comp. Endocrinol. 217-218 , 1-9, (2015)

Growth hormone (GH) regulates several processes in vertebrates, including two metabolically disparate processes: promotion of growth, an anabolic action, and mobilization of stored lipid, a catabolic ...

Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.

J. Immunol. 192(12) , 5776-88, (2014)

Recent compelling evidence indicates that Th17 confer host immunity against a variety of microbes, including extracellular and intracellular pathogens. Therefore, understanding mechanisms for the indu...

Cell migration towards CXCL12 in leukemic cells compared to breast cancer cells.

Cell. Signal. 28 , 316-24, (2016)

Chemotaxis or directed cell migration is mediated by signalling events initiated by binding of chemokines to their cognate receptors and the activation of a complex signalling cascade. The molecular s...


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Related Compounds

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