LasR-IN-4

Names

[ Name ]:
LasR-IN-4

Biological Activity

[Description]:

LasR-IN-4 is a potent LasR inhibitor. LasR-IN-4 can inhibit Pseudomonas aeruginosa and its biofilm formation, pyocyanin production, and rhamnolipids production[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

MIC: 56.25 μg/mL (P. aeruginosa)[1]

[In Vitro]

LasR-IN-4 (compound 3d) has inhibitory activity against P. aeruginosa with MIC of 56.25 μg/mL, and inhibits biofilm formation, pyocyanin production, and rhamnolipids production of 71.70%, 68.70% and 54.00%, respectively[1].

[References]

[1]. Abd El-Aleam RH, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₀N₄

[ Molecular Weight ]:
292.38

Related Compounds

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