Smurf1-IN-1

Names

[ CAS No. ]:
1824708-03-3

[ Name ]:
Smurf1-IN-1

Biological Activity

[Description]:

Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[Target]

IC50: 92 nM Specific E3ubiquitin protein ligase 1 (SMURF1)[1]


[References]

[1]. Shaw DE, et.al. Design and Synthesis of Inhibitors of the E3 Ligase SMAD Specific E3 Ubiquitin Protein Ligase 1 as a Treatment for Lung Remodeling in Pulmonary Arterial Hypertension. J Med Chem. 2023 Jun 22;66(12):8130-8139.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H29ClN6O2

[ Molecular Weight ]:
468.98

Related Compounds