clausine E

Names

[ CAS No. ]:
182261-83-2

[ Name ]:
clausine E

[Synonym ]:
methyl 1-hydroxy-9H-carbazole-3-carboxylate
1-Hydroxy-9H-carbazole-3-carboxylic acid methyl ester
clauszoline I
clauszoline-I
clausine-E

Biological Activity

[Description]:

Clausine E, is a alkaloid which can be isolated from Clausena excavata, is a inhibitor of fat mass and obesity-associated protein (FTO) demethylase. Clausine E shows inhibitory activities against proliferation of synoviocytes and cancer cells.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Wang Y, Li J, Han X, et al. Identification of Clausine E as an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. J Mol Recognit. 2019;32(10):e2800.  

[2]. Guo JM, Yu XM, Jiang B, et al. Zhongguo Zhong Yao Za Zhi. 2021;46(17):4438-4445.  

[3]. Liger F, Popowycz F, Besson T, Picot L, Galmarini CM, Joseph B. Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres. Bioorg Med Chem. 2007;15(16):5615-5619.  

Chemical & Physical Properties

[ Molecular Formula ]:
C14H11NO3

[ Molecular Weight ]:
241.24

[ Exact Mass ]:
241.07400

[ PSA ]:
62.32000

[ LogP ]:
2.81330

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds