Arzoxifene

Names

[ Name ]:
Arzoxifene

[Synonym ]:
Arzoxifene
UNII-E569WG6E60

Biological Activity

[Description]:

Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Metabolic Disease

[Target]

estrogen[1]

[In Vitro]

Arzoxifene reduces estrogen receptor expression in endometrial cancer cell lines (ECC-1)[1].

[In Vivo]

Arzoxifene inhibits MCF-7 breast cancer xenograft growth in oophorectomized athymic mice. Arzoxifene is reported to prevent body weight increase in oophorectomized rats[1].

[References]

[1]. Jackson LR, et al. Arzoxifene: the evidence for its development in the management of breast cancer. Core Evid. 2008;2(4):251-258.

Chemical & Physical Properties

[ Density]:
1.234g/cm3

[ Boiling Point ]:
656.4ºC at 760mmHg

[ Molecular Formula ]:
C₂₈H₂₉NO₄S

[ Molecular Weight ]:
475.59900

[ Flash Point ]:
350.8ºC

[ Exact Mass ]:
475.18200

[ PSA ]:
79.40000

[ LogP ]:
6.87740

[ Vapour Pressure ]:
7.85E-18mmHg at 25°C

[ Index of Refraction ]:
1.635

Arzoxifene

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Related Compounds