GlyT1 inhibitor 46

Names

[ CAS No. ]:
1820934-93-7

[ Name ]:
GlyT1 inhibitor 46

Biological Activity

[Description]:

GlyT1 Inhibitor 1 is a potent and selective GlyT1 inhibitor with an IC50 of 38 nM for rGlyT1[1]. Antipsychotic activity[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GlyT

[Target]

rGlyT1:38 nM (IC50)

[In Vivo]

GlyT1 Inhibitor 1 (Compound 46) demonstrates in vivo efficacy in a rat novel object recognition (NOR) assay after oral dosing at 0.1, 1, and 3 mg/kg[1].

[References]

[1]. Santora VJ, et al. Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties. J Med Chem. 2018 Jul 26;61(14):6018-6033.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₁N₅O₂

[ Molecular Weight ]:
387.43

Related Compounds

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