SPHINX31

Names

[ Name ]:
SPHINX31

Biological Activity

[Description]:

SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), which is a SRPK1 substrate. SPHINX31 is a potential topical therapeutic for neovascular eye disease[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> SRPK

[Target]

IC50: 5.9 nM (SRPK1)[1].

[References]

[1]. Batson J, et al. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₄F₃N₅O₂

[ Molecular Weight ]:
507.51

[ Storage condition ]:
2-8℃

Related Compounds

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