<Suppliers Price>

SR-4370

Names

[ CAS No. ]:
1816294-67-3

[ Name ]:
SR-4370

Biological Activity

[Description]:

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively.

[Related Catalog]:

Research Areas >> Cancer

[Target]

HDAC3:6 nM (IC50)

HDAC1:130 nM (IC50)

HDAC2:580 nM (IC50)

HDAC8:2300 nM (IC50)

HDAC6:3400 nM (IC50)


[In Vitro]

SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 μM, 0.58 μM, 0.006 μM, 2.3 μM, and 3.4 μM for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. SR-4370 is cytotoxic to the breast cancer cells (MDA-MB-231), with an IC50 of 12.6 μM[1].

[References]

[1]. LIAO, Daiqing, et al. HDAC INHIBITOR COMPOUNDS AND METHODS OF TREATMENT. WO 2015153516 A1.


[Related Small Molecules]

Trichostatin A | Entinostat (MS-275) | Romidepsin (FK228, Depsipeptide) | Mocetinostat(MGCD0103) | Ricolinostat (ACY-1215) | Sodium butyrate | RGFP 966 | Quisinostat | Tubacin | DL-Sulforaphane | CUDC-907 | LMK 235 | CI-994 | Tubastatin A | Sodium phenylbutyrate

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18F2N2O

[ Molecular Weight ]:
304.33

[ Storage condition ]:
2-8℃

Related Compounds