Ethiprole

Names

[ Name ]:
Ethiprole

[Synonym ]:
Ethiprole
UNII-5527E53JNB
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethylsulfinyl)-1H-pyrazole-3-carbonitrile
5-amino-1-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)-4-ethylsulfinylpyrazole-3-carbonitrile
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-ethylsulfinylpyrazole-3-carbonitrile
5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethanesulfinyl)-1H-pyrazole-3-carbonitrile

Biological Activity

[Description]:

Ethiprole is an insecticide.Metabolic sulfones are produced faster than Fipronil (HY-B0822) in CYP3A4-expressing cells and in vivo in mouse brain and liver.Ethiprole's sulfide, sulfoxide, sulfone and desulfinyl derivatives have better biological activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. Caboni P, Sammelson RE, Casida JE. Phenylpyrazole insecticide photochemistry, metabolism, and GABAergic action: ethiprole compared with fipronil. J Agric Food Chem. 2003 Nov 19;51(24):7055-61.

Chemical & Physical Properties

[ Density]:
1.69g/cm3

[ Boiling Point ]:
563.5ºC at 760mmHg

[ Melting Point ]:
~174°

[ Molecular Formula ]:
C₁₃H₉Cl₂F₃N₄OS

[ Molecular Weight ]:
397.20300

[ Flash Point ]:
294.6ºC

[ Exact Mass ]:
395.98300

[ PSA ]:
103.91000

[ LogP ]:
5.22618

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.655

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H373-H410

[ Precautionary Statements ]:
P273-P501

[ Target Organs ]:
Liver, Thyroid.

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T,N

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
UN2811 6.1/PG 3

Synthetic Route

Click to get detail synthetic route

Related Compounds

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