DT-061
Names
[ CAS No. ]:
1809427-19-7
[ Name ]:
DT-061
Biological Activity
[Description]:
DT-061 is an orally bioavailable activator of protein phosphatase 2A (PP2A) and could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis[1].
[Related Catalog]:
[Target]
PP2A[1].
[In Vivo]
DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1]. Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1]. Dosage: 5 mg/kg. Administration: Oral gavage for 4 weeks. Result: Showed activity in inhibiting tumor growth.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C25H23F3N2O5S
[ Molecular Weight ]:
520.52
[ Storage condition ]:
2-8℃