CHMFL-ABL-053
Names
[ CAS No. ]:
1808287-83-3
[ Name ]:
CHMFL-ABL-053
[Synonym ]:
5-Pyrimidinecarboxamide, 2-[(3-amino-4-methylphenyl)amino]-4-(methylamino)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-
2-[(3-Amino-4-methylphenyl)amino]-4-(methylamino)-N-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-5-pyrimidinecarboxamide
Biological Activity
[Description]:
CHMFL-ABL-053 is a potent, selective and orally available Bcr-Abl/Src/p38 kinase inhibitor with IC50 of 70/62/90 nM; no inhibitory activity against c-Kit (>10 uM); inhibits the proliferation of CML cell lines K562 (GI50=14 nM), KU812 (GI50=25 nM), and MEG-01 (GI50=16 nM); completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model with 50 mg/kg/day dosage treatment.
[References]
References 1. Liang X, et al. J Med Chem. 2016 Mar 10;59(5):1984-2004. View Related Products by Target Bcr-Abl
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Molecular Formula ]:
C28H26F3N7O2
[ Molecular Weight ]:
549.547
[ Exact Mass ]:
549.210022
[ LogP ]:
4.60
[ Index of Refraction ]:
1.698