BMS-986172

Names

[ CAS No. ]:
1808258-99-2

[ Name ]:
BMS-986172

Biological Activity

[Description]:

BMS-986172 is an orally active, highly selective MGAT2 inhibitor with an IC50 of 4.6 nM and 20 nM for hMGAT2 and mMGAT2, respectively. BMS-986172 has a T1/2>120 min in vitro assays. BMS-986172 reduces food intake and body weight. BMS-986172 has the potential for metabolic disorders such as obesity and NASH research[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. Wei Meng, et al. Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders. J Med Chem. 2023 Sep 28;66(18):13135-13147.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H22F7N7O3

[ Molecular Weight ]:
589.47

Related Compounds

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