Aminooxy-PEG3-acid

Names

[ Name ]:
Aminooxy-PEG3-acid

[Synonym ]:
Propanoic acid, 3-[2-[2-[2-(aminooxy)ethoxy]ethoxy]ethoxy]-
3-(2-{2-[2-(Aminooxy)ethoxy]ethoxy}ethoxy)propanoic acid
MFCD26127821

Biological Activity

[Description]:

Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
415.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₉NO₆

[ Molecular Weight ]:
237.250

[ Flash Point ]:
205.3±27.3 °C

[ Exact Mass ]:
237.121231

[ LogP ]:
-1.13

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.468

Aminooxy-PEG3-acid

Names

Biological Activity

Chemical & Physical Properties

Related Compounds