Acid-PEG2-SS-PEG2-acid

Names

[ Name ]:
Acid-PEG2-SS-PEG2-acid

[Synonym ]:
MFCD28950760
4,7,14,17-Tetraoxa-10,11-dithiaeicosane-1,20-dioic acid
4,7,14,17-Tetraoxa-10,11-dithiaicosane-1,20-dioic acid

Biological Activity

[Description]:

Acid-PEG2-SS-PEG2-acid is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
573.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₆O₈S₂

[ Molecular Weight ]:
386.481

[ Flash Point ]:
300.9±30.1 °C

[ Exact Mass ]:
386.106903

[ LogP ]:
0.69

[ Vapour Pressure ]:
0.0±3.4 mmHg at 25°C

[ Index of Refraction ]:
1.528

Related Compounds

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