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Benzyl-PEG5-Ms

Names

[ CAS No. ]:
1807539-07-6

[ Name ]:
Benzyl-PEG5-Ms

[Synonym ]:
MFCD28976666
1-Phenyl-2,5,8,11,14-pentaoxahexadecan-16-yl methanesulfonate
2,5,8,11,14-Pentaoxahexadecan-16-ol, 1-phenyl-, methanesulfonate
Benzyl-PEG5-MS

Biological Activity

[Description]:

Benzyl-PEG5-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
529.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H30O8S

[ Molecular Weight ]:
406.491

[ Flash Point ]:
274.0±30.1 °C

[ Exact Mass ]:
406.166138

[ LogP ]:
0.06

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.498

Related Compounds