Bis-PEG1-PFP ester

Names

[ Name ]:
Bis-PEG1-PFP ester

[Synonym ]:
MFCD26127804
Propanoic acid, 3,3'-oxybis-, bis(2,3,4,5,6-pentafluorophenyl) ester
Bis(pentafluorophenyl) 3,3'-oxydipropanoate

Biological Activity

[Description]:

Bis-PEG1-PFP ester is a non-cleavable (1 unit PEG) ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Research Areas >> Inflammation/Immunology

[Target]

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. CORTEZ, Alex, et al. ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST. WO2017072662A1.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
452.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₈F₁₀O₅

[ Molecular Weight ]:
494.237

[ Flash Point ]:
219.4±23.6 °C

[ Exact Mass ]:
494.021210

[ LogP ]:
4.99

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.460

Related Compounds

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