Aminooxy-PEG3-propargyl

Names

[ CAS No. ]:
1807537-27-4

[ Name ]:
Aminooxy-PEG3-propargyl

[Synonym ]:
AMINOXY-PEG3-PROPARGYL

Biological Activity

[Description]:

Aminooxy-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO2018204416A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
309.6±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₇NO₄

[ Molecular Weight ]:
203.236

[ Flash Point ]:
146.4±18.8 °C

[ Exact Mass ]:
203.115753

[ LogP ]:
-0.38

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.461

[ Storage condition ]:
2-8°C

Aminooxy-PEG3-propargyl

Names

Biological Activity

Chemical & Physical Properties

Related Compounds