Azido-PEG4-NHS-ester

Names

[ Name ]:
Azido-PEG4-NHS-ester

[Synonym ]:
1-[(14-Azido-3,6,9,12-tetraoxatetradecan-1-oyl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(14-azido-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)oxy]-

Biological Activity

[Description]:

Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₂N₄O₈

[ Molecular Weight ]:
374.346

[ Exact Mass ]:
374.143768

[ LogP ]:
-2.45

Azido-PEG4-NHS-ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds