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Mal-PEG3-PFP ester

Names

[ CAS No. ]:
1807534-78-6

[ Name ]:
Mal-PEG3-PFP ester

[Synonym ]:
Pentafluorophenyl 3-(2-{2-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy}ethoxy)propanoate
Propanoic acid, 3-[2-[2-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]ethoxy]ethoxy]-, 2,3,4,5,6-pentafluorophenyl ester
MFCD26127798

Biological Activity

[Description]:

Mal-PEG3-PFP ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
531.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H18F5NO7

[ Molecular Weight ]:
467.341

[ Flash Point ]:
275.3±30.1 °C

[ Exact Mass ]:
467.100342

[ LogP ]:
1.64

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.497

Related Compounds