Dde Biotin-PEG4-DBCO

Names

[ Name ]:
Dde Biotin-PEG4-DBCO

[Synonym ]:
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[19-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-
MFCD28505548
N-[19-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-15-(4,4-dimethyl-2,6-dioxocyclohexylidene)-19-oxo-3,6,9,12-tetraoxa-16-azanonadec-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

Biological Activity

[Description]:

Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1103.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₇H₆₁N₅O₉S

[ Molecular Weight ]:
872.080

[ Flash Point ]:
621.4±34.3 °C

[ Exact Mass ]:
871.419006

[ LogP ]:
3.80

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Storage condition ]:
-20°C

Related Compounds

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