ND-336

Names

[ Name ]:
ND-336

[Synonym ]:
1-(4-{4-[(2-Thiiranylmethyl)sulfonyl]phenoxy}phenyl)methanamine hydrochloride (1:1)
Benzenemethanamine, 4-[4-[(thiiranylmethyl)sulfonyl]phenoxy]-, hydrochloride (1:1)

Biological Activity

[Description]:

A selective inhibitor of the gelatinases MMP2 and MMP9 and MMP13 with Ki of 85, 150 and 120 nM, respectively; has minimal effect on other MMPs; accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound, thereby reversing the pathological condition.

[References]

References 1. Gao M, et al. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31. View Related Products by Target Matrix Metalloproteinase (MMP)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇NO₃S₂•HCl

[ Molecular Weight ]:
371.902

[ Exact Mass ]:
371.041656

[ Storage condition ]:
2-8°C

Related Compounds

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