N-(5-Hydroxypentyl)maleimide

Names

[ CAS No. ]:
180608-78-0

[ Name ]:
N-(5-Hydroxypentyl)maleimide

Biological Activity

[Description]:

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Non-cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].

[References]

[1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H13NO3

[ Molecular Weight ]:
183.20

[ Storage condition ]:
2-8°C

Related Compounds