Milvexian

Names

[ Name ]:
Milvexian

[Synonym ]:
BMS-986177

Biological Activity

[Description]:

Milvexian (BMS-986177), an effective antithrombotic agent, is an orally-bioavailable, reversible and direct inhibitor of human and rabbit factor XIa (FXIa) with Ki of 0.11, and 0.38 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[References]

[1]. Wong P, et al. Small-Molecule Factor XIa Inhibitor, BMS-986177/JNJ-70033093, Prevents and Treats Arterial Thrombosis in Rabbits at Doses that Preserve Hemostasis [abstract]. Res Pract Thromb Haemost. 2020; 4 (Suppl 1).

Chemical & Physical Properties

[ Density]:
1.60±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₂₃Cl₂F₂N₉O₂

[ Molecular Weight ]:
626.44

[ Storage condition ]:
2-8°C

Related Compounds

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