Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt

Names

[ CAS No. ]:
1802078-33-6

[ Name ]:
Mca-Amyloid β/A4 Protein Precursor770 (667-676)-Lys(Dnp)-Arg-Arg amide trifluoroacetate salt

[Synonym ]:
N-[(7-Methoxy-2-oxo-2H-chromen-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-lysyl-L-methionyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L- 
arginyl-L-argininamide
L-Argininamide, N-[2-(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-seryl-L-α-glutamyl-L-valyl-L-lysyl-L-methionyl-L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-N6-(2,4-di nitrophenyl)-L-lysyl-L-arginyl-

Biological Activity

[Description]:

Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[Target]

others

[References]

[1]. H Koike, et al. Thimet Oligopeptidase Cleaves the Full-Length Alzheimer Amyloid Precursor Protein at a β-Secretase Cleavage Site in COS Cells. J Biochem. 1999 Jul;126(1):235-42.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₈₇H₁₂₉N₂₇O₂₈S

[ Molecular Weight ]:
2033.184

[ Exact Mass ]:
2031.922119

[ LogP ]:
-2.08

[ Index of Refraction ]:
1.673

Related Compounds

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