RMC-3943

Names

[ CAS No. ]:
1801764-60-2

[ Name ]:
RMC-3943

Biological Activity

[Description]:

RMC-3943 is an allosteric SHP2 inhibitor (inhibition of full-length SHP2 in biochemical assay, IC50 = 2.19 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

[In Vitro]

RMC-3943 inhibits pERK in PC9 cells, with an IC50 of 35.5 nM[1]. RMC-3943 (0-10 μM) produces a concentration-dependent inhibition of proliferation of SK-MEL-113 cells[1]. Cell Viability Assay Cell Line: SK-MEL-113 cells[1]. Concentration: 0-10 μM. Incubation Time: 7 days. Result: Inhibited cell proliferation.

[References]

[1]. Efficacy of SHP2 phosphatase inhibition in cancers with nucleotide-cycling oncogenic RAS, RAS-GTP dependent oncogenic BRAF and NF1 loss. BioRxiv. 2021 Aug.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H22Cl2N6S

[ Molecular Weight ]:
425.38

Related Compounds