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Imidazole ketone erastin(IKE)

Names

[ CAS No. ]:
1801530-11-9

[ Name ]:
Imidazole ketone erastin(IKE)

Biological Activity

[Description]:

Imidazole ketone erastin (IKE) s a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Apoptosis >> Ferroptosis

[Target]

System Xc-, ferroptosis[1]


[References]

[1]. Zhang Y, et al. Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. Cell Chem Biol. 2019 Jan 31. pii: S2451-9456(19)30030-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C35H35ClN6O5

[ Molecular Weight ]:
655.14

[ Storage condition ]:
2-8℃

Related Compounds