JUSTICIDIN B

Names

[ Name ]:
JUSTICIDIN B

[Synonym ]:
4,5-dimethoxy-3',4'-methylenedioxy-2,7'-cycloligna-7,7'-dieno-9,9'-lactone
justicidin B

Biological Activity

[Description]:

Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Justicidin B 抑制致病真菌烟曲霉 (MIC ≥ 1 μg/mL)、黄曲霉 (MIC ≥ 12 μg/mL) 和白色念珠菌 (MIC ≥ 4 μg/mL) 的生长，但对新型隐球菌和头状芽孢杆菌无效[1]。 Justicidin B 还对罗得西亚布氏锥虫的锥体鞭毛体形式表现出很强的活性 (IC50 = 0.2 μg/mL)，对克氏锥虫 (IC50 = 2.6 μg/mL) 表现出中等活性[1]。 Justicidin B 在 MDA-MB-231 和 MCF-7 乳腺癌衍生细胞系中表现出细胞毒活性和诱导细胞凋亡。两种细胞系的 24 小时处理增加了凋亡 DNA 片段化的水平。MDA-MB-231 细胞与 Justicidin B 的接触导致 NFkB 表达的浓度依赖性降低；而 MCF-7 的处理与该转录因子表达的强烈增加一致[2]。

[References]

[1]. Jürg Gertsch, et al. Antifungal, antiprotozoal, cytotoxic and piscicidal properties of Justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta Med. 2003 May;69(5):420-4.

[2]. G Momekov, et al. Effect of justicidin B - a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines. Neoplasma. 2011;58(4):320-5.

[3]. Iliana Ionkova, et al. Linum narbonense: A new valuable tool for biotechnological production of a potent anticancer lignan Justicidine B. Pharmacogn Mag. 2013 Jan;9(33):39-44.

Chemical & Physical Properties

[ Density]:
1.376g/cm3

[ Boiling Point ]:
601.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₆O₆

[ Molecular Weight ]:
364.34800

[ Flash Point ]:
266ºC

[ Exact Mass ]:
364.09500

[ PSA ]:
63.22000

[ LogP ]:
3.92310

[ Vapour Pressure ]:
1.93E-14mmHg at 25°C

[ Index of Refraction ]:
1.658

Related Compounds

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